Robert J Levy Selected Research

Heart Valve Diseases (Valvular Heart Disease)

1/2022	Poly-2-methyl-2-oxazoline-modified bioprosthetic heart valve leaflets have enhanced biocompatibility and resist structural degeneration.
1/2021	Model studies of advanced glycation end product modification of heterograft biomaterials: The effects of in vitro glucose, glyoxal, and serum albumin on collagen structure and mechanical properties.
1/2019	Drug-associated valvular heart diseases and serotonin-related pathways: a meta-analysis.
7/2017	Serotonin and catecholamines in the development and progression of heart valve diseases.
5/2017	Calcification and Oxidative Modifications Are Associated With Progressive Bioprosthetic Heart Valve Dysfunction.
9/2009	Fenfluramine disrupts the mitral valve interstitial cell response to serotonin.
2/2007	Mechanisms of the in vivo inhibition of calcification of bioprosthetic porcine aortic valve cusps and aortic wall with triglycidylamine/mercapto bisphosphonate.
12/2005	Site specific gene delivery in the cardiovascular system.
12/2002	Serotonin mechanisms in heart valve disease II: the 5-HT2 receptor and its signaling pathway in aortic valve interstitial cells.
12/2002	Serotonin mechanisms in heart valve disease I: serotonin-induced up-regulation of transforming growth factor-beta1 via G-protein signal transduction in aortic valve interstitial cells.

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Robert J Levy Research Topics

Disease

10	Heart Valve Diseases (Valvular Heart Disease) 01/2022 - 12/2002
7	Thrombosis (Thrombus) 11/2022 - 05/2002
5	Inflammation (Inflammations) 12/2023 - 09/2002
4	Carcinoid Tumor (Carcinoid) 05/2020 - 12/2002
3	Aortic Valve Stenosis (Aortic Stenosis) 01/2020 - 02/2003
3	Aortic Valve Disease 01/2020 - 11/2004
3	Sclerosis 01/2020 - 02/2013
3	Neoplasms (Cancer) 05/2015 - 01/2014
3	Calcinosis 04/2010 - 03/2003
2	Pathologic Constriction (Stenosis) 01/2024 - 10/2018
2	Mitral Valve Insufficiency (Mitral Regurgitation) 01/2023 - 01/2018
2	Neuroblastoma 05/2015 - 05/2015
2	Cardiovascular Diseases (Cardiovascular Disease) 08/2010 - 03/2010
2	Vascular Diseases (Vascular Disease) 05/2010 - 12/2005
2	Cardiac Arrhythmias (Arrythmia) 12/2005 - 06/2003
1	Neointima 01/2024
1	Hypercholesterolemia 12/2023
1	Coronary Disease (Coronary Heart Disease) 01/2022
1	Parkinson Disease (Parkinson's Disease) 07/2017
1	Diabetes Mellitus 05/2017
1	Foreign Bodies (Foreign Body) 09/2014
1	Pneumonia (Pneumonitis) 04/2014
1	Pulmonary Edema 04/2014
1	Lung Injury 04/2014
1	Vascular Malformations 06/2012
1	Heart Diseases (Heart Disease) 01/2006
1	Coronary Artery Disease (Coronary Atherosclerosis) 01/2006
1	Long QT Syndrome 06/2003

Drug/Important Bio-Agent (IBA)

6	Serotonin (5 Hydroxytryptamine)IBA 05/2020 - 12/2002
5	Glutaral (Glutaraldehyde)IBA 01/2022 - 02/2007
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 12/2002
3	EnzymesIBA 04/2014 - 08/2010
3	AntioxidantsIBA 04/2014 - 08/2010
3	Transforming Growth Factor beta1 (TGF beta 1)IBA 03/2007 - 12/2002
2	Peptides (Polypeptides)IBA 12/2023 - 12/2002
2	Serotonin Plasma Membrane Transport Proteins (Serotonin Transporter)IBA 01/2023 - 01/2006
2	MetalsIBA 12/2020 - 01/2020
2	Dopamine Agonists (Dopamine Agonist)IBA 01/2019 - 07/2017
2	Appetite Depressants (Anorectics)IBA 01/2019 - 07/2017
2	FenfluramineIBA 07/2017 - 09/2009
2	Irinotecan (Camptosar)FDA LinkGeneric 05/2015 - 05/2015
2	ProdrugsIBA 05/2015 - 05/2015
2	Reactive Oxygen Species (Oxygen Radicals)IBA 09/2014 - 02/2013
2	CytokinesIBA 09/2014 - 04/2014
2	CatalaseIBA 04/2014 - 02/2013
2	Superoxide DismutaseIBA 04/2014 - 02/2013
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2024
1	Neurotransmitter Agents (Neurotransmitter)IBA 05/2020
1	Serotonin AgentsIBA 05/2020
1	Biomarkers (Surrogate Marker)IBA 01/2020
1	OsteopontinIBA 01/2020
1	OsteoprotegerinIBA 01/2020
1	Messenger RNA (mRNA)IBA 01/2020
1	RNA (Ribonucleic Acid)IBA 01/2020
1	PorphyrinsIBA 10/2018
1	CollagenIBA 10/2018
1	Serotonin ReceptorsIBA 01/2018
1	Phentermine (Adipex-P)FDA LinkGeneric 07/2017
1	CatecholaminesIBA 07/2017
1	FibrinIBA 05/2016
1	alpha-Tocopherol FDA Link 05/2015
1	Blood Proteins (Serum Proteins)IBA 09/2014
1	Reactive Nitrogen SpeciesIBA 09/2014
1	Immunoglobulin G (IgG)IBA 04/2014
1	EndotoxinsIBA 04/2014
1	Diphosphonates (Bisphosphonates)IBA 04/2010
1	Epoxy Compounds (Epoxides)IBA 04/2010
1	Collagenases (Collagenase)FDA Link 04/2010
1	triglycidylamineIBA 04/2010
1	Recombinant DNA (Recombinant DNA Research)IBA 03/2010
1	Alkaline PhosphataseIBA 03/2007
1	Matrix Metalloproteinase 9 (Gelatinase B)IBA 03/2007
1	Polyurethanes (Polyurethane)IBA 01/2006
1	CholesterolIBA 01/2006
1	Transcription Factors (Transcription Factor)IBA 11/2004
1	Potassium Channels (Potassium Channel)IBA 06/2003
1	Ion Channels (Ion Channel)IBA 06/2003
1	PotassiumIBA 06/2003
1	Transforming Growth Factor beta Receptors (TGF beta Receptors)IBA 12/2002
1	Transforming Growth Factor beta (TGF-beta)IBA 12/2002
1	Serotonin Receptor Agonists (Serotonin Receptor Agonist)IBA 12/2002
1	GTP-Binding Proteins (G-Protein)IBA 12/2002
1	Matrix Metalloproteinases (MMPs)IBA 09/2002
1	Microfilament Proteins (Actin Binding Proteins)IBA 09/2002
1	thymosin beta(4)IBA 09/2002
1	PlatinumIBA 05/2002

Therapy/Procedure

11	Stents 01/2024 - 12/2005
4	Therapeutics 01/2022 - 06/2003
2	Drug-Eluting Stents 12/2020 - 01/2020
2	Bioprosthesis 02/2007 - 03/2003
1	Percutaneous Coronary Intervention 01/2022
1	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 05/2017
1	Aftercare (After-Treatment) 05/2015
1	Intravenous Injections 04/2014
1	Heart Valve Prosthesis 01/2006